2Y3A: Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941

PDB ID: 2Y3ADownload
MMDB ID: 89155
PDB Deposition Date: 2010/12/20
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 2Y3A: dimeric; determined by software (PISA)
Molecular Components in 2Y3A
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta Isoform
(Gene symbol: Pik3cb)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Beta
(Gene symbol: Pik3r2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303